名师讲座

报告题目：Is pharmaceutical analysis undergoing a revolution?

报告时间：2026-11-06 09:30

报告人： Davy Guillarme 副教授

University of Geneva

报告地点：卢嘉锡楼202报告厅

转播地点：翔安校区能源材料大楼3号会议室2；漳州校区生化主楼312教室

报告摘要：

The development of drugs is highly regulated, since their quality, safety and efficacy must be demonstrated at every stage. Drug substances may contain impurities arising from synthesis, degradation products or, in the case of biologics, variants generated during production and storage. Their characterization and quantification are therefore essential to verify compliance with specifications, detect changes that could affect safety, and ensure batch-to-batch consistency. For decades, liquid chromatography has been widely used for pharmaceutical analysis and is considered a gold standard, thanks to its ability to separate the components of complex mixtures.

The pharmaceutical landscape is now changing rapidly. Alongside with small molecules, we have seen an increasing number of peptides and proteins, monoclonal antibodies, antibody-drug conjugates, fusion proteins, cell and gene therapies, and nucleic-acid-based medicines. These products are often much larger and structurally more heterogeneous, with closely related variants that can be difficult to distinguish. Chromatographic methods originally designed for small molecules therefore do not always meet current analytical needs. Chromatographic strategies must be reconsidered to improve speed and selectivity, facilitate mass spectrometry (MS) detection, and automate analysis.

This presentation will cover four complementary areas: accelerating the analysis of therapeutic proteins using very short columns; improving chromatographic selectivity to distinguish closely related molecular variants; Improving MS compatibility for native chromatographic modes; and developing online multidimensional methods coupled with MS for characterization of variants at different structural levels.

报告人简介：

Davy Guillarme, Ph.D. in analytical chemistry from the University of Lyon, currently serves as an associate professor at the University of Geneva in Switzerland. With almost 400 published journal articles in pharmaceutical analysis and h-index of 86, his expertise spans various techniques, including HPLC/UHPLC, HILIC, LC−MS, SFC, SFC-MS, multidimensional LC, and analysis of biopharmaceuticals.

He is an editor of the Journal of Chromatography A and serves on the editorial advisory board of prestigious journals like Trends in Analytical Chemistry, Journal of Chromatography B, Journal of Separation Science.

Davy Guillarme has been honored with the LC-GC Emerging Leader Award in Chromatography (2013), Jubilee Medal from the Chromatographic Society (2018), International Award of the Belgian Society of Pharmaceutical Sciences (2022), Csaba Horvath memorial award (2025), J.F.K. Huber lecture award (2026). He has also been listed among the world's most influential analytical scientists by "Analytical Scientist" magazine in multiple years.

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化学化工学院

来源：化学化工学院　学术讲座　原文链接：https://chem.xmu.edu.cn/info/1275/128805.htm　转载日期：2026-11-05

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